The purpose of this research study is to compare the effects of higher dose vitamin D with commonly recommended dose in pregnant women to see which is better in achieving and/or maintaining sufficient vitamin D blood levels during pregnancy and in newborn infants as well as improving growth in the infant.
Three dosages of Vitamin D will be administered; 400IU, 2000IU and 4000IU per day to pregnant women starting at less than 16 week gestation continued until delivery. The dose will be provided using a randomized control method. Serum levels of 25 hydroxy D will be measured in mothers at 12, 16, 28 and delivery. Cord blood 25 hydroxy D and the infants' birthweight, length and head circumference will be measured at birth.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
DOUBLE
Enrollment
192
Once daily, prenatal vitamin containing 400IU of Vitamin D, until delivery
Once daily, 1600IU dose of Vitamin D from 12 weeks gestation to delivery
Once daily, 3600IU dose of Vitamin D, from 12 weeks until delivery
Cincinnati Children's Hospital Medical Center
Cincinnati, Ohio, United States
United Arab Emirated Unitersity
Al Ain City, Abu Dhabi Emirate, United Arab Emirates
Maternal Serum and Neonatal Serum 25-hydroxyvitamin D Measurement
Maternal serum 25-hydroxyvitamin D measurement at 12, 16, 28 weeks during pregnancy and at delivery and cord blood or neonatal serum 25-hydroxyvitamin D measurement
Time frame: 12, 16, 28 weeks and at maternal delivery and neonatal birth
Growth of the Newborn Infant as Measured by Crown-heel Length and Head Circumference at Birth
Growth of the newborn infant as measured by crown-heel length in centimeters and head circumference in centimeters at birth
Time frame: At delivery
Birthweight of Newborn Infant
Growth of the Newborn Infant as Measured by Birthweight in grams.
Time frame: Measured at birth.
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