Imaging of Prostate Cancer Using Two-dimensional MR Spectroscopy and Diffusion Tensor Imaging

University of California, Irvine

Overview

The goal is to develop MR imaging techniques to improve delineation of cancer extent, and to improve differential diagnosis between prostate cancer and benign prostate hyperplasia or other benign diseases.

Study Type

INTERVENTIONAL

Allocation

Purpose

DIAGNOSTIC

Masking

NONE

Conditions

Prostate Lesions

Interventions

magnetic resonance imagingDEVICE

MR contrast agent (0.1 mmol/kg)

Eligibility

Sex: MALEMin age: 21 YearsMax age: 80 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: 1. A male older than 21 years of age and under age of 80, 2. Either a normal healthy volunteer; a patient who has confirmed prostate cancer and decided to receive prostatectomy; or a patient who has persistent elevated PSA higher than 4.0 ng/ml, and with a prior benign biopsy scheduled to receive the second biopsy. Exclusion Criteria: 1. Unwilling to give informed consent, 2. Have implanted prosthetic heart valves, pacemaker, neuro-stimulation devices, surgical clips (hemostatic clips) or other metallic implants, 3. Have engaged in occupations or activities which may cause accidental lodging of ferromagnetic materials, or have imbedded metal fragments from military activities, 4. Have received orthodontic work involving ferromagnetic materials, 5. Claustrophobic, 6. Unable to lie down still for 60 minutes.

Locations (1)

Center for Functional Onco-Imaging, University of California

Irvine, California, United States

Outcomes

Primary Outcomes

To demonstrate that multi-voxel MR spectroscopy and diffusion tensor imaging can accurately diagnose prostate cancer and benign diseases, also to provide an accurate disease extent.

Time frame: at completion of the study

Data from ClinicalTrials.gov

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