The Effects of Facilitated Percutaeous Coronary Intervention in Acute Myocardial Infarction

Samsung Medical Center40 enrolled

Overview

The purpose of this study to investigate whether the administration of high-dose tirofiban before primary PCI could reduce myocardial infarct size, using analysis of contrast-enhanced magnetic resonance imaging.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Acute Myocardial Infarction

Interventions

tirofibanDRUG

tirofiban (25 μg/kg bolus and 0.15 μg/kg/min maintenance infusion for 24 hours)

Eligibility

Sex: ALLMin age: 18 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * presence of chest pain for more than 30 minutes but less than 12 hours after symptom onset * ST-segment elevation more than 1 mm in two or more contiguous leads or presumably a new-onset left bundle branch blockage Exclusion Criteria: * hemodynamic instability * history of MI * old age \> 80years * Patients with bleeding diathesis (coagulopathy, thrombocytopenia or platelet dysfunction, Gastrointestinal or genitourinary bleeding within the prior 3 months)

Outcomes

Primary Outcomes

Infarct size and its transmural extent using MRI

Time frame: within the first 30 days after index procedure

Secondary Outcomes

pre-PCI thrombolysis in myocardial infarction grade, post-PCI myocardial blush grade, ST-segment resolution on electrocardiography, and left ventricular ejection fraction on echocardiography

Time frame: at 6 month after index procedure

Data from ClinicalTrials.gov

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