BLYS and IFN in SLE

University of Alabama at Birmingham39 enrolled

Overview

This protocol tests whether changes in BLyS or IFN can be detected in a normal immune response to a vaccine and, if so, whether the response differs between those with lupus and healthy controls.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Systemic Lupus Erythematosus

Interventions

fluzoneBIOLOGICAL

once

pneumovaxBIOLOGICAL

once

Eligibility

Sex: ALLMin age: 19 YearsMax age: 65 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * ACR lupus criteria * 18\<age\<65 Exclusion Criteria: * chronic infection or cancer * pregnancy

Locations (1)

University of Alabama at Birmingham

Birmingham, Alabama, United States

Outcomes

Primary Outcomes

change in specific antibodies in response to vaccine

Time frame: 2 weeks

Secondary Outcomes

change in BLyS after vaccination

Time frame: 2 weeks

change in IFN after vaccination

Time frame: 2 weeks

Data from ClinicalTrials.gov

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