The Effect of Sertindole on Sensory Gating and Cognition in Healthy Volunteers

Inclusion Criteria: * Age: 18-40 * Gender: male Exclusion Criteria: * Axis I Disorders: lifetime DSM IV diagnosis according to DIA-X of alcohol or illicit drug dependence. No life-time DSM IV diagnosis according to DIA-X of a major affective, psychotic, anxiety disorder, eating-disorder as defined above. * Axis II Disorders: lifetime DSM IV diagnosis of personality disorder according to SCID-II. * Family history: lifetime history of 1st degree relative (parents and siblings) of a major affective, psychotic, or anxiety disorder as defined above. * ECG: QTc-interval \>450 msec. * Systolic blood pressure \<100 mmHg * Bradycardia (Hf \< 50/Min) und Arrhythmias * Hypokalemia or Hypomagnesemia