A Phase I Study of Monoclonal Antibody TB-402 in Healthy Male Volunteers

Inclusion Criteria: * Males 18 to 45 (Groups 1-9) or 55 to 75 (Group 10) years of age * No clinically important abnormal physical, laboratory, ECG findings * Normal (or abnormal but ncs) supine blood pressure (BP) and heart rate (HR) Exclusion Criteria: * Self or family history of cardiovascular or pulmonary disorder, coagulation or bleeding disorders or reasonable suspicion of vascular malformations eg cerebral haemorrhage, aneurysm or premature stroke. * Any autoimmune disease. * Previous allergic reaction to immunoglobulin. * Present, or history of, severe allergy, for example asthma or anaphylactic reactions or allergy requiring treatment. * Consumption of aspirin, other non-steroidal anti-inflammatory drugs or other drugs known to affect platelet function or any other aspect of coagulation within 14 days before drug administration. * Abnormal platelet function or clinically significant out of range values for any coagulation tests. * History of important bleeding episodes eg haematemesis, rectal bleeding, severe or recurrent epistaxis, haemoptysis, haematuria or intracranial haemorrhage. * Screening FVIII:C \< 50%.