Near Normalisation of BG Improves the Potentiating Effect of GLP-1

Hvidovre University Hospital9 enrolled

Overview

The ability of glucagon-like peptide 1 to enhance beta-cell responsiveness to I.v. glucose is impaired in patients with type 2 diabetes mellitus compared with healthy individuals. We investigated whether 4 weeks of near-normalisation og blood glucose improves the potentiation of glucose-stimulated insulin secretion by GLP-1

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

SINGLE

Enrollment

Conditions

Diabetes Mellitus Type 2

Interventions

glucagon-like peptide-1DRUG

continuous infusion of GLP-1 (1½ pmol/kg/min)

SalineDRUG

continuous infusion of saline

Eligibility

Sex: ALLMin age: 18 YearsMax age: 70 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Age 18-70 years * Type 2 diabetes diagnosed after 30 years of age * BMI \> 25 Exclusion Criteria: * Severe complications to diabetes * Abnormal liver og kidney function * Haemoglobin below the lower limit * Macroalbuminuria * Systemic disease * Pregnancy

Locations (1)

Dept. of Endocrinology, Hvidovre Hospital

Copenhagen, Denmark

Outcomes

Primary Outcomes

insulin secretion rate (ISR) were derived by deconvolution of c-peptide. ISR is expressed as pmol/kg/min

Time frame: 180 minutes

Secondary Outcomes

The calculated ISR values was plotted against the ambient plasma glucose. The slopes of this linear relationships were calculated by cross-correlation analysis and is and estimation of beta-cell responsiveness (pmol/kg/min)/mmol/l

Time frame: 180 minutes

Data from ClinicalTrials.gov

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