Beta-Cell Function After Near-Normalisation of Blood Glucose

Hvidovre University Hospital8 enrolled

Overview

The incretin effect is attenuated in patients with type 2 diabetes mellitus partly due to impaired potentiation of beta-cell responsiveness to glucose by glucose dependent insulinotropic polypeptide and glucagon-like peptide-1 respectively. The aim of the present study was to investigate whether 4 weeks of near-normalization of blood glucose could improve the insulin responses to GIP and GLP-1 in patients with type 2 diabetes.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

SINGLE

Enrollment

Conditions

Type 2 Diabetes

Interventions

glucagon-like peptide-1,DRUG

GLP-1:continuous infusion of ½ pmol/kg/min for a total time of 120 minutes.

glucose dependent insulinotropic polypeptideDRUG

continuous infusion of GIP (1½ pmol/kg/min) for 120 min.

SalineDRUG

continuous infusion of Saline for 120 min

Eligibility

Sex: ALLMin age: 18 YearsMax age: 70 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Age 18-70 years * Type 2 diabetes diagnosed after 30 years of age * BMI \> 25 Exclusion Criteria: * Severe complications to diabetes * Abnormal liver and kidney function * Haemoglobin below the lower limit * Macroalbuminuria * Systemic disease * Pregnancy

Locations (1)

Dept. of Endocrinology, Hvidovre Hospital

Copenhagen, Denmark

Outcomes

Primary Outcomes

2.phase insulin response measured as incremental area under the curve from 10-120 minutes

Time frame: 2 hours

Secondary Outcomes

2.phase insulin response measured as incremental area under the curve from 10-120 minutes, after 4 weeks of insulin treatment

Time frame: 2 hours

Data from ClinicalTrials.gov

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