Advanced MRI in Major Depression

University of Aarhus49 enrolled

Overview

Depression is the most common psychiatric disorder. * 3-5% of a given population has major depression. * Less than 50% of the depressed in Denmark are diagnosed with major depression. * 25-50% of the depressed have a relative with major depression-underlying brain pathology? The purpose of this study is to use MRI to evaluate cerebral morphology and function in ambulant patients with major depression

Previous studies within major depression, have often included hospitalized patients with severe symptoms and imaging have been performed with PET and SPECT, which uses ionizing radiation. This study focus on ambulant patients(with or without medication/ECT treatment), to find patients in an earlier stage. Cerebral perfusion with the MR sequence Arterial Spin Labelling, concentrations of different metabolites with MR spectroscopy and brain volumetry with BRAVO 3D T1 ax will be performed. MR protocol: T2 sag, T2 FLAIR ax, ASL ax, MRS and 3D T1 ax. Scan time 45 min.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Depressive Disorder, Major

Interventions

Magnetic Resonance ImagingOTHER

* Morphological sequences * Arterial Spin Labelling (Perfusion) * Spectroscopy: anterior cingulate cortex Naa, Cho, Cr, Myo-inositol, glutamate TE 30 Reference voxel in Parietal white matter

Eligibility

Sex: ALLMin age: 20 YearsMax age: 65 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Patients who fulfil ICD-10´s criteria for major depression, found within the ambulant psychiatric sector and who has a HAM-D ≥ 18 Exclusion Criteria: * If the patient has pacemaker or other magnetic devices * Pregnancy * Has had an operation in the brain * bipolar disorder

Locations (1)

Aalborg Hospital / Aarhus University Hospital

Aalborg, Jutland, Denmark

Outcomes

Primary Outcomes

Differences in morphological and functional cerebral MRI findings in patients suffering from major depression

Time frame: 6 months from first MRI in each patient

Data from ClinicalTrials.gov

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