The purpose of this study is to determine the effectiveness of proton beam radiotherapy combined with chemotherapy for treatment of locally advanced non-small cell lung cancer.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
28
A five week coarse of proton radiotherapy begins on day 28 and is given once daily for the first two weeks and twice daily for the final 3 weeks. The total dose given with proton beam is 76 Gy. Weekly chemotherapy with carboplatin and taxol is given during proton therapy.
200 mg/m2, IV, for 2 cycles followed by 50 mg/m2 weekly for 5 weeks during radiotherapy.
AUC 6, IV, for two cycles followed by AUC 2 weekly for 5 weeks during radiotherapy.
Loma Linda University Medical Center
Loma Linda, California, United States
Overall Survival.
Median survival time following treatment.
Time frame: Monthly for duration of participant lifespan. Average lifespan 1-2 years
Treatment Related Toxicities.
grade 3 or higher esophageal toxicity Toxicity is categorized either early or late phase. Early phase- toxicity occurring during or within 30 days s/p treatment Late phase- toxicity occurring thereafter
Time frame: Monthly for duration of participant lifespan. Average lifespan 1-2 years
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