Inheritance of Osteosarcoma & Paget's Disease Through Chromosome 18:

State University of New York - Upstate Medical University8 enrolled

Overview

Researchers have previously demonstrated loss of heterozygosity in a region on chromosome 18q, associated with osteogenic sarcomas in bone affected by Paget's disease. The loci used in this study are specifically described by those authors as showing loss of heterozygosity in 6 of 7 affected families.

As above, no additional information

Study Type

OBSERVATIONAL

Enrollment

Conditions

Osteosarcoma Paget's Disease

Eligibility

Sex: ALL

Medical Language ↔ Plain English

Inclusion Criteria: * This is a familial study therefore the only inclusion/exclusion criteria would be that subjects must be a blood relative and over the age of 18. * The subjects are proband and father along with unaffected blood relatives. Their peripheral blood will act as a control and provide information to delineate the inheritance from the father, as seen in the son. Exclusion Criteria: * Not part of the family

Locations (1)

SUNY Upstate Medical University

Syracuse, New York, United States

Outcomes

Primary Outcomes

Loss of heterozygosity

A loss of heterozygosity of a proposed tumor suppressor gene on chromosome 18

Time frame: January, 2000 through February 2009

Data from ClinicalTrials.gov

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