Study of Immunoadsorption to Treat Severe Atopical Dermatitis Associated With Excessively High Serum IgE Levels

Inclusion Criteria: * Atopical dermatitis * Total serum IgE level above 5000 kU/l * IGA score of 3 or above * No sufficient response to topical corticosteroids/calcineurin inhibitors, UV therapy (at least 4 weeks of therapy), systemic corticosteroids and cyclosporin A (at least 8 weeks of therapy) or no possibility of a prolonged use of this therapy due to adverse events/contraindications * 18 years of age or above * Effective contraception during therapy * Informed consent Exclusion Criteria: * Unfavorable conditions for peripheral venous access * Known hypersensitivity or allergy towards materials used in the adsorber columns * Adequate anticoagulation not possible (e.g. multiple allergies towards various anticoagulants) * Extreme bleeding tendency during anticoagulation * Hypercoagulability * Severe cardiovascular disease forbidding extracorporeal circulation * Severe systemic infection * Serum IgG level below 250 mg/dl * Severe immunodeficiency (e.g. AIDS) * Treatment with an ACE inhibitor (discontinue drug at least 72 h before treatment) * Pregnancy * Lactation * A condition that, in the opinion of the investigator, would preclude participation in the study (e.g. chronic alcoholism or mental dysfunction)