Zonisamide in the Treatment of Essential Tremor

Loma Linda University9 enrolled

Overview

The purpose of this study is to determine if Zonisamide is effective in reducing tremors in patients with Essential Tremor.

The subjects will remain on their usual medication and a baseline assessment using the Fahn Tolosa Marin tremor rating scale will be performed and will be video taped.

Study Type

INTERVENTIONAL

Allocation

Purpose

TREATMENT

Masking

SINGLE

Enrollment

Conditions

Essential Tremor

Interventions

ZonisamideDRUG

100mg tablets once a day for two weeks, then increased to 200mg qhs for two weeks.

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. Diagnosis of Essential Tremor based on the Tremor Investigational Group criteria for definite or probable Essential Tremor. 2. Age: 18 years or over. 3. Willingness and ability to comply with the study requirements and give informed consent. Exclusion Criteria: 1. Known history of psychiatric disorder, major depression, dementia, aplastic anemia, or Stevens-Johnson syndrome. 2. Known alcohol or substance abuse in previous 12 months. 3. Positive pregnancy test. 4. Unwillingness to use adequate contraceptive methods if of childbearing potential. 5. Known allergy to sulfonamides. 6. Laboratory abnormalities prior to onset of trial.

Outcomes

Primary Outcomes

Tremor Severity

PI has left the institution and we are unable to accurately assess the data from the remaining records.

Time frame: 4 weeks

Data from ClinicalTrials.gov

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