Low frequency (1Hz) rTMS applied bilaterally and simultaneously over SMA for 6 weeks in addition to the standard treatment regimen for OCD, will lead to significant improvement in patients' symptoms. The clinical improvement detected by YBOCS, CGI and SF-36 QOLS scores will be statistically significant in active treatment group compared to sham (placebo) treatment group.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Enrollment
24
6 weeks of stimulation with RMT frequency 1Hz, intensity 110% of RMT for 20 minutes, 5 minutes of trains with 2 minutes of intra-train intervals to both SMA. Treatment will be given 5 times a week for 4 weeks, 3 times a week during Week 5 and 2 times a week during Week 6.
Sham treatment will mimic active treatment mentioned above.
Military Medical Academy
Sofia, Bulgaria
Providence Care, Mental Health Services
Kingston, Ontario, Canada
Dokuz Eylul University
Izmir, Turkey (Türkiye)
Yale-Brown Obsessive Compulsive Scale (YBOCS)
Time frame: pre, week 1, 2, 4, 6, 8, 12
Clinical Global Impression
Time frame: pre, week 1, 2, 4, 6, 8, 12
Hamilton Depression Rating Scale-21(HDRS)
Time frame: pre, week 1, 2, 4, 6, 8, 12
Pittsburgh Sleep Quality Index (PSQI)
Time frame: pre, week 1, 2, 4, 6, 8, 12
Hamilton Anxiety Rating Scale (HARS)
Time frame: pre, week 1, 2, 4, 6, 8, 12
SF-36 QOLS version (1)
Time frame: pre, week 1, 2, 4, 6, 8, 12
Visual Analogue Scale
Time frame: pre, week 1, 2, 4, 6, 8, 12
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