Injection of Autologous CD34-Positive Cells for Critical Limb Ischemia

Inclusion Criteria: * 21-80 years of age * moderate or high-risk Critical Limb Ischemia (Rutherford Clinical Severity Score 4 or 5) * unsuitable for conventional revascularization Exclusion Criteria: * advanced CLI (Rutherford Clinical Severity Score 6) characterized by extensive tissue loss or gangrene * advance AV block or NYHA Class III or Class IV heart failure * myocardial infarction within 3 months of treatment * successful coronary or lower extremity revascularization within 3 months of study enrollment * arterial insufficiency in the lower extremity is the result of a non-atherosclerotic disorder with the exception of thromboangitis obliterans (Buerger's Disease) * co-morbidity associated with life expectancy of less than 1 year