H9 Priming Study in Healthy Adults

Inclusion Criteria: * Male or non-pregnant female (as indicated by a negative urine pregnancy test immediately prior to vaccine administration) between the ages of 18 and 38 years, inclusive, or 44-59 years, inclusive. * Women of childbearing potential who are at risk of becoming pregnant must agree to practice adequate contraception (e.g., barrier method, abstinence, and licensed hormonal methods) from at least 30 days prior to enrollment and for at least 3 months after receipt of dose 2. * Be in good health, as determined by vital signs (heart rate less than 100 beats per minute, blood pressure systolic less than or equal to 140 mm Hg and greater than or equal to 90 mm Hg; diastolic less than or equal to 90 mm Hg, oral temperature less than 100 degrees Fahrenheit), medical history and a targeted physical examination based on medical history. (Stable medical condition - no change in prescription medication, dose or frequency of medication in the last 3 months and health outcomes of the specific disease are considered to be within acceptable limits in the last 6 months. Any change that is due to change of health care provider, insurance company etc, or that is done for financial reasons, as long as in the same class of medication will not be considered a violation of this inclusion criterion. Any change in prescription medication due to improvement of a disease outcome will not be considered a violation of this inclusion criterion.) * Able to understand and comply with planned study procedures. * Provide informed consent prior to initiation of any study procedures and be available for all study visits. Exclusion Criteria: * Has a known allergy to eggs or other components of the vaccine including thimerosal. * Has a positive urine pregnancy test prior to vaccination (if female of childbearing potential), is breast-feeding, or has the intention to become pregnant within 3 months of receipt of their second dose of vaccine. * Is undergoing immunosuppression as a result of an underlying illness or treatment. * Has an active neoplastic disease or a history of any hematologic malignancy. * Is using oral or parenteral steroids, high-dose inhaled steroids (greater than 800 micrograms/day of beclomethasone dipropionate or equivalent) or other immunosuppressive or cytotoxic drugs. * Has a history of receiving immunoglobulin or other blood product within the 3 months prior to enrollment in this study. * Has a diagnosis of schizophrenia, bipolar disease or other major psychiatric diagnosis. * Has received any other licensed vaccines within 2 weeks (for inactivated vaccines) or 4 weeks (for live vaccines) prior to enrollment in this study. * Has an acute or chronic medical condition that, in the opinion of the investigator, would render vaccination unsafe or would interfere with the evaluation of responses (this includes, but is not limited to: known chronic liver disease, significant renal disease, unstable or progressive neurological disorders, diabetes mellitus, and transplant recipients). * Has a history of severe reactions following immunization with contemporary influenza virus vaccines. * Has an acute illness, including an oral temperature greater than 100.4 degrees Fahrenheit, within 1 week of vaccination. * Has received an experimental agent (vaccine, drug, biologic, device, blood product, or medication) within 1 month prior to each vaccination in the study, or expects to receive an experimental agent during the 7-month study period. * Prior receipt of influenza A/H9N2 vaccine, other than the present study. * Is planning to enroll in another clinical trial at any time during the study period (approximately 7 months total). * Has known active human immunodeficiency virus, hepatitis B or hepatitis C infection. * Has a history of alcohol or drug abuse in the last 5 years. * Has a history of Guillain-Barré syndrome. * Have been hospitalized for psychiatric illness, history of suicide attempt or confinement for danger to self or others. * Are receiving psychiatric drugs (aripiprazole, clozapine, ziprasidone, haloperidol, molindone, loxapine, thioridazine, thiothixene, pimozide, fluphenazine, risperidone, mesoridazine, quetiapine, trifluoperazine, trifluopromazine, chlorprothixene, chlorpromazine, perphenazine, olanzapine, carbamazepine, divalproex sodium, lithium carbonate or lithium citrate). Subjects who are receiving a single antidepressant drug and stable for at least 3 months prior to enrollment, without de-compensating symptoms will be allowed to be enrolled in the study. * Plan to travel outside of the USA in the time between the first vaccination and 56 days following the first vaccination. * Has any condition that would, in the opinion of the site investigator, place the subject at an unacceptable risk of injury or render the subject unable to meet the requirements of the protocol. * Has any condition that the investigator believes may interfere with successful completion of the study.