Maternal Immunization To Prevent Infant Otitis Media

Inclusion Criteria: Maternal inclusion criteria: * Pregnant, at least 18 yrs of age and healthy based on medical history. * Plans to continue HealthPartners insurance coverage until infant is 13 mos old; mother and child will receive care in staff model clinic participating in the study, and obstetric care will be provided by a HP obstetrician/CNM with delivery at affiliated hospital. * Plans to reside in Twin Cities metro area until infant is 13 mos old. * Has a residence phone and a back-up phone contact. * Provides informed consent. Infant inclusion criteria: * Infants born to enrolled women. Exclusion Criteria: Maternal exclusion criteria: * Known hypersensitivity to any of the vaccine components or to latex. * Prior vaccination with any S. pneumoniae vaccine. * Recent (w/in 2 mos) vaccination with diphtheria or tetanus-diphtheria toxoid vaccines. Administration of influenza, or any other vaccine, or RhoGAM in the 2 wks prior to administration of the study product. * Known history of life-threatening pneumococcal infection. * Known impairment of immunologic function or history of immunodeficiency. * Previous child with a major congenital anomaly or fetal malformation. * Known to be carrying more than one fetus. * Any medical condition or history that, in the opinion of the investigator, may interfere with the evaluation of the study objectives. * History of preterm birth or fetal death. * Known history of chronic hypertension, severe pre-eclampsia in a previous pregnancy, current pre-eclampsia or any type of diabetes mellitus. * Known anatomical defects of the cervix or uterus. * Known history of teratogenic drug use or illegal substance abuse during current pregnancy, not including tobacco or alcohol use. * Women who have tested positive (based on medical record information) for HIV or hepatitis B infection. * Any contraindication specified in the vaccine manufacturer's CIB. * History of febrile illness (temp 100.0 degrees F or over) during the 72 hrs prior to vaccine administration. * History of significant mental illness (e.g. schizophrenia, psychoses, major depression). Infant exclusion criteria: * Hypersensitivity to any component of the vaccine, including diphtheria toxoid. * Thrombocytopenia or any coagulation disorder that would contraindicate intramuscular injection. * Latex sensitivity. * Known impaired immune responsiveness, whether due to the use of immunosuppressive therapy (including irradiation, corticosteroids, antimetabolites, alkylating agents, and cytotoxic agents), a genetic defect, HIV infection, or other causes that may reduce antibody response to active immunization. * Vaccination may be delayed because of a current or recent febrile illness depending largely on the severity of the symptoms and their etiology. Although a severe or even a moderate febrile illness is sufficient reason to postpone vaccinations, minor illnesses, such as a mild upper respiratory infection with or without low-grade fever, are not generally contraindications.