Antihypertensive Response to Losartan and Genetic Polymorphisms

Inclusion Criteria: * Both gender less than 60 years old, with mild-moderate hypertension (SBP greater than and DBP equal or greater than 90 mmhg, BP \< 180/110) * Never treated for hypertension or who have taken antihypertensive agents sporadically (not more than 15 days total therapy) but not in the 30 days prior to the first visit * Patient in therapeutic wash out for 6 months * Patient is asymptomatic, absence of significant concomitant diseases, except for non-familial hypercholesterolemia, absence of systemic diseases * Women with menopause not treated with hormone replacement therapy or women of reproductive age who do not make use of estro-progestagen agents but who use another safe contraceptive method * BMI \< 30 for men and \< 28 for women Exclusion Criteria: * Secondary or malignant hypertension, Na \<130 mmol/l, K \>5,5 mmol/l, or \< 3,0 mmol/l * Cardiac disease such as ischemic, HF, arrhythmia, cardiac surgery * Pregnant, breast feeding * History of nephropathy, metabolic disease, liver disease * Alcohol or drug abuse * History of angioedema * Has a known hypersensibility to study drug(s)