Haemate HS in Patients With Severe Bleeding Undergoing Valve Replacement Due to Aortic Stenosis

Inclusion Criteria: * patients with isolated valvular aortic stenosis or combined aortic-valve defect with prevailing stenosis with severe bleeding during aortic-valve replacement * Caucasian * written informed consent (Classification of bleeding as "normal", "moderate" or "excessive" by the surgeon.Classification as excessive leads to recruitment) Exclusion Criteria: * active endocarditis * history suggestive for inherited oe acquired bleeding disorder * concomitant coronary heart disease * agents impairing platelet function up to 14 days before surgery * Pregnancy * inherited platelet function * known intolerance against HAEMATE HS * previous thromboembolic complications * Hepatitis B, C or HIV infection * previous chemotherapy * emergency surgery within the last 7 days * weight \< 50 kg and \> 100 kg