Insulin Secretory Capacity in Insulin-independent Pancreas-Kidney Recipients Compared to Controls

University Hospital, Gasthuisberg40 enrolled

Overview

The purpose of this study is to compare functional beta-cell mass using the hyperglycaemic clamp test in insulin-independent pancreas-kidney recipients with that in non-diabetic kidney recipients and normal controls as well as with the partially previously reported data in beta-cell recipients.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

DIAGNOSTIC

Masking

NONE

Enrollment

Conditions

Kidney Transplantation Pancreas Transplantation

Interventions

hyperglycemic clamp testOTHER

hyperglycemic clamp test

Eligibility

Sex: ALLMin age: 21 YearsMax age: 65 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * kidney pancreas recipients * kidney recipients * healthy volunteers * beta-cell recipients * immunosuppression with MMF-Tacrolimus * 1-4 years after transplantation Exclusion Criteria: * high doses of steroids * insulin dependent

Locations (1)

Department of Endocrinology, Leuven, UZ-Gasthuisberg

Leuven, Belgium

RECRUITING

Outcomes

Primary Outcomes

insulin secretion during clamp test

Time frame: time 0

Central Contacts

Chantal Mathieu, M.D., PhD.

CONTACT

0032/16/346994 chantal.mathieu@uz.kuleuven.ac.be

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.