Endothelial Dysfunction and Coronary Artery Spasm

N/ACompletedNCT00619294

Kumamoto University158 enrolled

Overview

Non-obstructive coronary artery disease (NOCAD) frequently accounts for myocardial ischemia in women. Endothelial dysfunction is a pathogenic factor in coronary spastic angina (CSA). CSA is an important cause of NOCAD diagnosed invasively by coronary angiography (CAG). Digital reactive hyperemia peripheral arterial tonometry (RH-PAT) provides noninvasive evaluation of endothelial dysfunction. The investigators hypothesized that the fingertip RH-PAT could predict the presence of CSA in women.

Outline of methods: RH-PAT was measured in women with chest pain prior to CAG. Coronary spasm was diagnosed by intra-coronary acetylcholine (ACh) provocation test. Using Flow-Wire, we assessed coronary endothelial function by coronary blood flow increase in response to ACh (ACh-CBF) and coronary flow reserve was assessed by adenosine (Ad-CFR).

Study Type

OBSERVATIONAL

Enrollment

158

Conditions

Coronary Vasospasm

Eligibility

Sex: FEMALEMin age: 40 YearsMax age: 90 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Stable post-menopausal women complaining angina-like chest pain Exclusion Criteria: * Severe valvular disease * Hypertrophic cardiomyopathy * Severe peripheral artery disease * Uncontrolled hypertension * Severe collagen diseases * Acute coronary syndrome

Locations (1)

Kumamoto University Hospital

Kumamoto, Kumamoto, Japan

Outcomes

Primary Outcomes

Ischemic heart disease diagnosed by cardiac catheterization

Time frame: From Aug 2006 to May 2009

Data from ClinicalTrials.gov

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