Proximal Molecular Effects of Concurrent Chemoradiotherapy on Head and Neck Squamous Cell Carcinoma

Inclusion Criteria: * Untreated HNSCC (\> Stage I) amenable to transoral biopsy. * Scheduled for concurrent CRT (Cisplatin or Carboplatin/5-FU based) as definitive primary treatment * Older than 18 years of age. * Understand and sign informed consent. Exclusion Criteria: * Any prior treatment of the index cancer (chemotherapy, immunotherapy, hormonal therapy or radiation therapy) or similar treatment of an unrelated malignancy within 6 weeks of enrollment into this study. * Breast-feeding, pregnancy or of childbearing potential (including those women who are less than two years post menopausal) and unable to confirm adequate contraception (abstinence, IUD, birth control pills, or spermicidal gel with diaphragm or condom) since last menses. * History of chronic inflammatory disease (e.g. ulcerative colitis, Crohn's disease, rheumatoid arthritis or pancreatitis). * Corticosteroid use within 6 weeks of enrollment, excluding topical nasal sprays. * NSAID (including celecoxib) or aspirin (\> 81 mg/day) use within 1 week of enrollment. * Investigational medication use within 6 weeks of enrollment or is scheduled to receive an investigational drug during the course of the study.