We hypothesise that fish oils will have a beneficial effect on cardiometabolic parameters in women with PCOS. The purpose of this study therefore is to examine the effects of fish oils on blood pressure, heart rate variability and liver fat content in obese women with the polycystic ovary syndrome.
The prevalence of abnormalities of blood pressure (ABP), variability of heart rate (HRV) and liver fat content is increased in women with the polycystic ovary syndrome (PCOS). We hypothesise that fish oils will have a beneficial effect on these endpoints and other cardiometabolic parameters such as cholesterol and liver function in women with PCOS. This crossover study of 40 obese women with PCOS will therefore examine the effects of fish oils on the above parameters compared with placebo (olive oil). Subjects with PCOS who have participated in previous studies with this research group will be approached for recruitment, as will eligible subjects within the endocrine clinics of the chief and co-investigators.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Enrollment
40
1000mg capsules, 4 capsules/day for 8 weeks
Olive oil capsules, 4 per day for 8 weeks
School of Medicine and Pharmacology, Royal Perth Hospital
Perth, Western Australia, Australia
24 hour ambulatory systolic blood pressure
Time frame: week 8 and week 24
24 hour heart rate variability
Time frame: week 8 and week 24
liver fat content (MRI)
Time frame: week 8 and week 24
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