The hypothesis of this study is that the p38 inhibitor (PH-797804) will be safe and well tolerated in subjects with rheumatoid arthritis who are taking methotrexate and will not effect the blood levels of methotrexate.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Enrollment
27
Pfizer Investigational Site
Phoenix, Arizona, United States
Pfizer Investigational Site
Colorado Springs, Colorado, United States
Pfizer Investigational Site
Miami, Florida, United States
Pfizer Investigational Site
Frederick, Maryland, United States
Adverse events, laboratory data, vital signs, 12-lead ECGs and physical examination findings
Time frame: 6 weeks
Estimate the effects of multiple doses of PH-797804 on the pharmacokinetic profile of methotrexate in subjects with RA taking a stable dose of MTX
Time frame: 6 weeks
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Pfizer Investigational Site
Bingham Farms, Michigan, United States
Pfizer Investigational Site
Kalamazoo, Michigan, United States
Pfizer Investigational Site
Duncansville, Pennsylvania, United States