Extended-release Naltrexone for Alcohol Dependence in Primary Care

Inclusion Criteria: * Current alcohol dependence * Age 18 or older * English or Spanish-speaking * Without untreated severe mental illness * Liver enzymes (alanine aminotransferase and aspartate aminotransferase) ≤ 3x normal * Kept 2 of last 3 clinic primary care appointments and/or has a working telephone number at which can be contacted directly * Either a) currently abstinent (e.g., referred from an inpatient 'detox' setting) or b) with the ability, in the clinician's judgment, to achieve and maintain abstinence * If female of child-bearing potential, must be using adequate contraception * Able to understand study procedures Exclusion Criteria: * Currently opioid dependent or requiring ongoing treatment with opioids for any indication