Efficacy and Safety Study Comparing Lorazepam and Diazepam for Children in the Emergency Department With Seizures (Status 2)

Inclusion Criteria: 1. Age 3 months to less than 18 years; 2. Generalized tonic clonic status epilepticus, defined as: 1. Three or more generalized tonic clonic seizures within the last hour and currently experiencing a convulsion (i.e. the current convulsion may be the third convulsion within one hour); or 2. Two or more generalized tonic clonic seizures in succession with no recovery of consciousness between seizures and currently experiencing a convulsion (i.e. the current convulsion may be the second convulsion without recovery of consciousness after the first convulsion); or 3. A seizure that lasts at least 5 minutes that is either generalized tonic clonic in its entirety or starts focal and then generalizes. The seizure must be associated with loss of consciousness Exclusion Criteria: 1. Pregnancy; 2. Shock prior to study drug (sustained hypotension requiring inotropic therapy); 3. Significant dysrhythmia prior to study drug (other than sinus tachycardia); 4. Need for emergent surgical intervention and general anesthesia for a condition present prior to study drug; 5. Known sensitivity to benzodiazepines or known contraindication to benzodiazepine use; or 6. Use of a benzodiazepine within 1 week of presentation. Certain exclusion criteria may not be known at the time of drug administration due to the need for emergent treatment. Thus patients will be terminated from the study (early terminators) if the investigators discover any of the following conditions after administration of study drug: 1. Pregnancy; 2. Use of a benzodiazepine within 1 week of presentation. 3. Parent/guardian refusal to give informed consent by the methods described; 4. Patient's refusal to assent (for patients ≥ 7 yrs old and mentally competent to understand study procedures) by the methods described, or as required by the local IRB;