Surveillance of Ocular Surface Flora (SURFACE)

N/ACompletedNCT00621933

Allergan399 enrolled

Overview

Topical fluoroquinolones (FQs) have achieved widespread use in ophthalmology for both the treatment and prophylaxis of ocular infections. The present study is set to determine the bacteria present on the ocular surface in patients at the time of cataract surgery and to assess the rate of resistance of ocular isolates to commonly used topical antibiotics.

Study Type

OBSERVATIONAL

Enrollment

399

Conditions

Cataract

Eligibility

Sex: ALLMin age: 50 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Scheduled to undergo cataract surgery * Able to provide written informed consent Exclusion Criteria: * NSAID in the eye to be swabbed within the past 30 days * Topical anesthetic, topical antibiotic or antiseptic, or dilating drops in the eye to the swabbed within the past 7 days * Over-the-counter artificial tear drops or astringent /redness reliever drops (e.g., Visine®, Clear eyes® in the eye to be swabbed on the day of trial * History of conjunctivitis or any ocular infection within the past 3 months

Locations (1)

Unnamed facility

Salt Lake City, Utah, United States

Outcomes

Primary Outcomes

Percentage of Staphylococcus Epidermidis Species Susceptible and Resistant to Oxacillin on the Eyelid

Percentage of staphylococcus epidermidis species susceptible and resistant to oxacillin on the eyelid. The minimum inhibitory concentrations (MIC) of each species were determined and compared to oxacillin MIC breakpoints. MIC is the lowest concentration of an antimicrobial that inhibits the visible growth of a microorganism after incubation. For Staphylococcus epidermidis, the oxacillin MIC breakpoints were \<= 0.25 ug/ml (susceptible) and \>= 0.50 ug/ml (resistant).

Time frame: Baseline

Percentage of Staphylococcus Epidermidis Species Susceptible and Resistant to Oxacillin on the Conjunctiva

Percentage of staphylococcus epidermidis species susceptible and resistant to oxacillin on the conjunctiva . The minimum inhibitory concentrations (MIC) of each species were determined and compared to oxacillin MIC breakpoints. MIC is the lowest concentration of an antimicrobial that inhibits the visible growth of a microorganism after incubation. For Staphylococcus epidermidis, the oxacillin MIC breakpoints were \<= 0.25 ug/ml (susceptible) and \>= 0.50 ug/ml (resistant).

Time frame: Baseline

Secondary Outcomes

Percentage of Staphylococcus Aureus Species Susceptible and Resistant to Oxacillin on the Eyelid

Percentage of staphylococcus aureus species susceptible and resistant to oxacillin on the eyelid. The minimum inhibitory concentrations (MIC) of each species were determined and compared to oxacillin MIC breakpoints. MIC is the lowest concentration of an antimicrobial that inhibits the visible growth of a microorganism after incubation. For Staphylococcus aureus, the oxacillin MIC breakpoints were \<= 2 ug/ml (susceptible) and \>= 4 ug/ml (resistant).

Time frame: Baseline

Percentage of Staphylococcus Aureus Species Susceptible and Resistant to Oxacillin on the Conjunctiva

Percentage of staphylococcus aureus species susceptible and resistant to oxacillin on the conjunctiva. The minimum inhibitory concentrations (MIC) of each species were determined and compared to oxacillin MIC breakpoints. MIC is the lowest concentration of an antimicrobial that inhibits the visible growth of a microorganism after incubation. For Staphylococcus aureus, the oxacillin MIC breakpoints were \<= 2 ug/ml (susceptible) and \>= 4 ug/ml (resistant).

Data from ClinicalTrials.gov

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