Randomised Study Comparing Three Chemotherapy Regimens in Non-small Cell Lung Cancer

Inclusion Criteria: * Histological or cytological diagnosis of non-small cell lung cancer * Advanced (unresectable or functionally inoperable) stage III or stage IV disease * Availability for participating in the detailed follow-up of the protocol * Presence of an evaluable or measurable lesion * Informed consent Exclusion Criteria: * Prior treatment with chemotherapy * Operable patient with resectable tumour * Performance status \< 60 on the Karnofsky scale * A history of prior malignant tumour, except non-melanoma skin cancer or in situ carcinoma of the cervix and cured malignant tumour (more than 5-year disease free interval) * Polynuclear cells \< 2,000/mm³ * Platelet cells \< 100,000/mm³ * Serum bilirubin \>1.5 mg/100 ml * Serum creatinine \> 1.5 mg/100 ml and/or creatinine clearance \< 60 ml/min * Perception hypoacousia * Peripheral neuropathy * Recent myocardial infarction (less than 3 months prior to date of diagnosis) * Congestive cardiac failure requiring medical therapy or uncontrolled cardiac arrhythmia * Uncontrolled infectious disease * Serious medical or psychological factors which may prevent adherence to the treatment schedule