Gemcitabine With Antiangiogenic Peptide Vaccine Therapy in Patients With Pancreatic Cancer

Inclusion Criteria: DISEASE CHARACTERISTICS 1. locally advanced or metastatic pancreatic cancer precluding curative surgical resection and recurrent pancreatic cancer 2. measurable disease by CT scan PATIENT CHARACTERISTICS 1. ECOG performance status 0-2 2. Life expectancy \> 3 months 3. Laboratory values as follows * 2000/mm3 \< WBC \< 15000/mm3 * Platelet count \> 75000/mm3 * Bilirubin \< 3.0 mg/dl * Aspartate transaminase \< 150 IU/L * Alanine transaminase \< 150 IU/L * Creatinine \< 3.0 mg/dl 4. HLA-A\*2402 5. Able and willing to give valid written informed consent Exclusion Criteria: 1. Pregnancy(woman of childbearing potential:Refusal or inability to use effective means of contraception) 2. Breastfeeding 3. Active or uncontrolled infection 4. Concurrent treatment with steroids or immunosuppressing agent 5. Prior chemotherapy of gemcitabine 6. Prior chemotherapy,radiation therapy, or immunotherapy within 4 weeks 7. Serious or nonhealing wound, ulcer, or bone fracture 8. Active or uncontrolled other malignancy 9. Ileus 10. Interstitial pneumonia 11. Decision of unsuitableness by principal investigator or physician-in-charge