Phase I Study of SB-480848(Darapladib) -Repeat Dose Study in Healthy Japanese Male Subjects-

Inclusion criteria: * Healthy Japanese adult males between 20 and 64 yeas of age, inclusive. * Healthy subjects are defined as individuals who are free from clinically significant disease as determined by their medical history, physical examination, clinical laboratory examinations, vital sign, 12-lead ECG, immunology tests and urinary drug screen test. * Bodyweight \>50 kg and body mass index (BMI) between 18.5 and 25.0 at screening. * Subjects must be capable of providing written informed consent, which includes compliance with the requirements and restrictions listed in the consent form. * Baseline QTc interval \<450 msec. * Non-smoker or ex-smoker having ceased smoking for at least 6 months. * Clinical laboratory examination (AST, ALT, ALP and GGT) at screening are within the normal range. * The subject is able to attend all visits and complete the study. Exclusion criteria: * Any clinically relevant abnormality identified on the screening physical examination, vital sign measurement, 12-lead ECG recording and/or clinical laboratory examination that is deemed by the principal investigator and/or medical monitor to make the subject ineligible for inclusion because of a safety concern. * History of regular alcohol consumption exceeding, on average, 14 drinks/week for men (1 drink = 5 ounces (150 mL) of wine or 350 mL of beer or 1.5 ounces (45 mL) of 80 proof distilled spirits) within 6 months of screening. * Positive for urine drug at screening. * Positive for syphilis, HIV antibody, Hepatitis B surface antigen, Hepatitis C antibody or HTLV-1 antibody at screening. * Use of prescription or no-prescription drugs, including vitamins, herbal and dietary supplements (including St John's Wort) within 7 days or 5 half-lives (whichever is longer) prior to the first dose of study medication. * Consumption of grapefruit juice or food within 7 days prior to the first dose of study medication. * A history of cholecystectomy or biliary tract disease including a history of liver disease with elevated liver function tests of known or unknown etiology. * Donation of blood in excess of 400mL within 4 months or 200mL within 1 months prior to at screening. * History of drug abuse, or current conditions of drug abuse or alcoholism. * Participation in a clinical study or post-marketing study with an investigational or a non-investigational product or device within 4 months of preceding the first dose of study medication. * Participation in another clinical study or post-marketing study in which the subject is or will be exposed to an investigational or a non-investigational product or device. * History of asthma, anaphylaxis or anaphylactoid reactions, severe allergic responses. * The subject has an allergy for any drug or idiosyncrasy. This excludes a pollen allergy without current symptoms. * History of sensitivity to heparin or heparin-induced thrombocytopenia.