China Cimicifuga Trial of Climacteric Complaint Control

Inclusion Criteria: * Having climacteric symptoms with hot flushes \>= 3 time per day * Score of Kupperman Index at baseline \>= 20 * In addition to these criteria, women who had menopause longer than 2 months but less than 12 months, with FSH \> 15U/L were enrolled into the perimenopausal group. Women having menopause longer than 12 months but less than 5 years, with FSH \>= 40U/L and E2 \<= 30pg/ml, were assigned into early staged postmenopausal group. Exclusion Criteria: * Having history of hysterectomy * Having HRT within 6 weeks * Having other drugs or nutritional supplements of relieving climacteric symptoms within one week * Having psychological counseling within one week * Having medical history of estrogen-dependent tumors * The result of pap smear exam at stage III and above * Having an uterine leiomyoma lager than 4 cm * The endometrial thickness lager than 0.5 cm * Having abnormal cardiac, liver or kidney functions * Having abnormal thyroid function * Having hypertension, diabetes and coronary heart diseases that were not under control * Pregnant or suspected pregnant woman * Having severe mental disorders that inhibit to understand the research purpose * Other conditions the investigators believed not suitable for enrollment