The purpose of this study was to determine if treating patients who have coronary heart disease with hyperbaric oxygen (HBO) prior to coronary artery bypass graft (CABG) surgery reduces injury to the heart and vascular system during and after surgery. Furthermore, this study also aims to identify some of the post CABG clinical effects of HBO treatment prior to CABG.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
HEALTH_SERVICES_RESEARCH
Masking
SINGLE
Enrollment
81
100% Oxygen at 2.4 ATA for 30 minutes followed by 5 minutes break followed by 100% Oxygen at 2.4 ATA for another 30 minutes. This intervention was given about 4 to 5 hours prior to CABG
Hull & East Yorkshire NHS Trust (Castle Hill Hospital)
Hull, East Riding Of Yorkshire, United Kingdom
Myocardial Hsp72 protein
Time frame: Intra-operative (During CABG)
Myocardial eNOS protein
Time frame: Intra-Operative (During CABG)
Serum Troponin-T
Time frame: Peri-operative
Serum soluble ICAM-1
Time frame: Peri-operative
Serum soluble PSGL-1
Time frame: Peri-operative
Serum soluble P-Selectin
Time frame: Peri-operative
Serum soluble E-Selectin
Time frame: Peri-operative
All cardiovascular haemodynamic parameters as measured by a pulmonary artery catheter
Time frame: Peri-operative
Duration of mechanical ventilation
Time frame: Post Operative
Duration of endotracheal intubation
Time frame: post operative
Length of stay in ICU
Time frame: Post-operative
Blood loss
Time frame: Post operative
Inotrope usage
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Time frame: Post operative
Atrial Fibrillation
Time frame: Post operative
Low cardiac output status
Time frame: Post operative
Pulmonary complications
Time frame: Post operative
Renal Complications
Time frame: Post operative
Cerebrovascular complications
Time frame: Post operative
Gastrointestinal complications
Time frame: Post operative
Wound complications
Time frame: Post operative
Cost of ICU stay
Time frame: Post operative