Procrit Versus Placebo to Determine Efficacy in Pre-Operative Major Surgical Oncology Operations

Inclusion Criteria: * Undergoing a major surgical oncology procedure as defined below: * Pancreatectomy * Hepatectomy * Esophagectomy * Gastrectomy * Retroperitoneal Sarcoma Resection * 18 years of age and older * Hemoglobin level of ≥ 10g/dL to \< 13g/dL, within 10 days of enrollment * If female of child-bearing potential, negative pregnancy test within 14 days prior to surgery * If subject is a sexually active male or a sexually active female of child- bearing potential, subject agrees to use a medically accepted form of contraception from the time of enrollment to completion of all follow-up study visits * IRB-approved informed consent, signed by the subject or the subject's legally authorized representative ≥ 18 years of age Exclusion Criteria: * Pre-operative hemoglobin level ≥ 13g/dL or \< 10g/dL * Uncontrolled hypertension (defined as a systolic pressure ≥ 160 and/or a diastolic pressure ≥ 110) * History of allergy to Procrit® * Known hypersensitivity to mammalian cell-derived products or human albumin * History of spontaneous venous thrombotic vascular events * Anemia due to factors other than cancer,(e.g. iron deficiency, B12 deficiency) * History of (within 12 months) deep venous thrombosis (DVT), pulmonary embolus (PE), or other venous thrombotic events. Prior superficial thrombophlebitis is not an exclusion criterion * History of (within 6 months) uncontrolled cardiac arrhythmias, cerebrovascular accident (CVA), transient ischemic attack (TIA), acute coronary syndrome (ACS), or other arterial thrombosis. ACS includes Unstable Angina, Q wave Myocardial Infarction (QwMI), and non-Q wave myocardial infarction (NQMI) * Currently receiving therapeutic or prophylactic anticoagulants for conditions other than planned surgery. The only exceptions are low dose aspirin (≤ 325 mg/day) or low dose anticoagulant to maintain patency of intravenous (IV) lines * Patient is a candidate for autologous blood transfusion