The Role of COX-2 Inhibition in Salt Sensitivity of Blood Pressure

University of Delaware12 enrolled

Overview

The purpose of this study is to determine if the drug Celebrex changes the way the kidney gets rid of salt and maintains blood pressure.

There have been many studies done with analgesics such as acetaminophen and non-steroidal anti-inflammatory drugs; however it is not understood how blood pressure changes while using Celebrex. The study hypothesis is that Celebrex will increase salt sensitivity of blood pressure.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

DOUBLE

Enrollment

Conditions

Hypertension

Interventions

celecoxib (Celebrex)DRUG

Celecoxib (Celebrex) was administered at 100 mg, twice per day for each day of sodium diet

PlaceboOTHER

Placebo pill taken twice per day on each day of the diet

Eligibility

Sex: ALLMin age: 22 YearsMax age: 50 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * healthy men and women Exclusion Criteria: * history of heart disease * have had heart surgery * high blood pressure * diabetes * cancer * any other disease such as kidney or neurological diseases * taking medications such as aspirin or medicines for your heart or blood pressure * have asthma or are allergic to sulfa drugs * body mass index greater than 30 * use tobacco * pregnant * women using oral contraceptives or hormone replacement therapy

Locations (1)

University of Delaware

Newark, Delaware, United States

Outcomes

Primary Outcomes

Mean Arterial Pressure

Blood pressure was measured on the last day of each 7 day sodium diet for 24 hours using an ambulatory blood pressure monitor

Time frame: 24 hours

Secondary Outcomes

Urinary Sodium Excretion

Urine collected over 24 hour period on last day of each different sodium diet

Time frame: 24 hour

Data from ClinicalTrials.gov

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