A Double-Blind, Placebo-controlled Crossover Study of Repeat Rivastigmine Administration in Healthy Male Volunteers

Inclusion Criteria: * Healthy Caucasian males between 18 and 40 years (inclusive) of age. * No known history of significant neurological, renal, cardiovascular, respiratory (asthma), endocrinological, gastrointestinal, hematopoietic disease, neoplasm or any other clinically significant medical disorder, which in the investigator's judgment contraindicate administration of the study medications. * Subjects within BMI 18-29 (inclusive) calculated as Weight (Kg)/Height (m)2. * Non-smoking (by declaration) for a period of at least 6 months. * No history of drug or alcohol abuse. * Subjects with negative urinary drugs of abuse screen (Appendix 2) determined within 21 days of the start of the study. * Negative HIV, Hepatitis B or Hepatitis C serology tests within 21 days of the first study session. * Subjects must be able to adhere to the visit schedule and protocol requirements and be available to complete the study. * Subjects must be fluent in Hebrew * Subjects must satisfy a medical examiner about their fitness to participate in the study. * Subjects must provide written informed consent to participate in the study. Exclusion Criteria: * • Known hypersensitivity to the drug, components or other carbamates. * History of or currently active asthma or chronic obstructive pulmonary disease. * History of or currently active cardiac arrhythmias such as bradycardia and sick sinus syndrome * History of urinary tract obstruction. * History of or currently active GI diseases such as peptic ulcer, GERD, bleeding or history of any GI surgery other than appendectomy or herniotomy, or with any gastrointestinal disorder likely to influence drug absorption, or with any history of anorexia, frequent nausea or emesis, regardless of etiology. * Significant abnormalities in screening physical exam * Significant abnormalities in clinical laboratory parameters (hematology, biochemistry, serology, urinalysis). Parameters to be measured are those shown in Appendix 2. * Significant abnormalities in ECG within 21 days of the start of the study. * Subjects with significant allergic response to other drugs. * Adherence (for whatever reason) to an abnormal diet during the 4 weeks prior to the study, or subjects with recent significant change in body weight. * Subjects who have taken anticholinergic or other drugs known to affect gastrointestinal motility within 7 days prior to the first dosing. * Use of any prescription or over-the-counter (OTC) medications, including vitamins and herbal or dietary supplements within 7 days prior to the first study dosing or during the study. Paracetamol for symptomatic relief of pain is allowed until 24 hours prior to the trial (see section 10.1). * Subjects who donated blood in the three months preceding the first study dosing or intend to make blood donation during the study, or within the three months following the study completion. * Subjects who received blood or plasma derivatives in the 3 months preceding the first study dosing. * Participation in another clinical trial with drugs within 3 months prior first study dosing. * Subjects with an inability to communicate well with the investigators and CRC staff (i.e., language problem, poor mental development or impaired cerebral performance). * Subjects that have difficulty fasting or consuming the standard meals that will be provided. * Subjects with any acute medical situation (e.g. acute infection) within 48 hours of study start, which is considered of significance by the Principal Investigator. * Subjects who are non-cooperative or unwilling to sign a consent form.