Oxygen radicals and inflammation are important causes for brain injury in neonates following perinatal asphyxia. Animal studies demonstrated potential benefits to the brain when using both of vitamin C and ibuprofen. The efficacy of these 2 drugs when combined in protecting the human brain has not been studied. We aimed in this study to test the hypothesis that a combination of anti-oxidants (vitamin C) and anti-inflammatory (ibuprofen) drugs can decrease the brain injury in perinatal asphyxia and improve outcomes when given to infants immediately after birth.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Enrollment
60
IV, 100 mg/kg/day, every day, for 3 days
PO, 10 mg/kg on day 1, 5 mg/kg/day on days 2 and 3 of life
Bab El-Shariya Hospital
Cairo, Cairo Governorate, Egypt
DDST-II
Time frame: 6 months
Neurological Examination
Time frame: 6 months
Death
Time frame: On Discharge
Neurological Examination
Time frame: On Discharge
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