Aortic Dimensions in Turner Syndrome

University of Aarhus102 enrolled

Overview

An observational study of 102 women with Turner syndrome followed for 6 years with a two-yearly examination including ECHO, MRI of the heart and 24 ambulatory blood pressure. It has been found that besides an significantly increased risk of congenital cardiac malformations, TS have an increased risk of developing cardiac disease including the life threatening condition of aortic dilatation and rupture. The aim of the study is to describe the cardiac conditions of TS, evaluate different methods of examination and identify possible risc factors.

Study Type

OBSERVATIONAL

Enrollment

102

Conditions

Turner Syndrome

Eligibility

Sex: FEMALEMin age: 18 YearsMax age: 70 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Turner syndrome * Age 18-70 years Exclusion Criteria: * Extreme adipositas * Contraindications to a MRI scan * Malignant disease

Outcomes

Primary Outcomes

Aortic diameter at 3 well-defined levels measured by MRI and ECHO

Time frame: 2-yearly for 6 years

Secondary Outcomes

24hour ambulatory blood pressure

Time frame: 24h 2-yearly for 6 years

Data from ClinicalTrials.gov

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