Long Term Follow-up of Bone Mineral Density in Hormone Treated Turner Syndrome

University of Aarhus54 enrolled

Overview

Turner Syndrome (TS) is associated with osteopenia and osteoporosis. Reduced bone mineral density (BMD) and increased risk of fractures are present in many younger and middle-aged women with TS. The objective is therefore to describe longitudinal changes in BMD in TS. The study is an observational follow-up study. Examinations at baseline, after 5 and 10 years. Bone mineral density is measured by dual energy x-ray absorptiometry (DEXA) and bone turnover by bone markers. Main Outcome Measures: Bone mineral density (BMD; grams/ square centimetre) were measured at lumbar spine, hip and the non-dominant forearm.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Turner Syndrome

Eligibility

Sex: FEMALEMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Turner syndrome verified by karyotyping Exclusion Criteria: * untreated hypothyroidism or hyperthyroidism * present or past malignant diseases * clinical liver disease * treatment with drugs known to interfere with bone metabolism (e.g. glucocorticoids)

Outcomes

Primary Outcomes

Bone Mineral Density in columna lumbalis, collum femoris and distal ulnae Bone mineral density (BMD; grams/ square centimetre) were measured at lumbar spine, hip and the non-dominant forearm.

Time frame: Evey 5 years

Data from ClinicalTrials.gov

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