The benefit of current reperfusion therapies for ST-elevation myocardial infarction (STEMI) is limited by post-infarction left ventricular (LV) dysfunction. Many clinic trails showed the short term outcome of bone marrow stem cell transplantation for MI patients, but rare report of long term follow-up results. Our aim was to investigate 4 years' efficacy and LV functional improvement of autologous bone marrow mononuclear cells (BMMC) transplantation in patients with ST-elevation myocardial infarction.
The benefit of current reperfusion therapies for ST-elevation myocardial infarction (STEMI) is limited by post-infarction left ventricular (LV) dysfunction. Many clinic trails showed the short term outcome of bone marrow stem cell transplantation for MI patients, but rare report of long term follow-up results. Aim is to evaluate the long term efficiency of unselected bone marrow mononuclear cells in treatment of patients with ST-elevation myocardial infarction (STEMI), especially with regard to the left ventricular function. The cells are delivered by intracoronary infusion 7 days after the PCI. Outcomes including LVEF, myocardial viability and coronary artery status are assessed by echocardiography, SPECT and coronary angiography.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
37
Patients receive intracoronary injections of saline 7 days after PCI.
Patients receive intracoronary injections of autologous bone marrow mononuclear cells 7 days after PCI.
Department of Cardiology in Xijing Hospital
Xi'an, Shaanxi, China
Left Ventricular Ejection Fraction(LVEF)
Time frame: 1, 3, 6 months, 1, 4 years
in-stent restenosis
Time frame: 1, 3, 6 months, 1, 4 years
cardiac shock
Time frame: 1, 3, 6 months, 1, 4 years
myocardial viability of the infarcted area
Time frame: 1, 3, 6 months, 1, 4 years
end-diastolic Volume/end-systolic Volume(EDV/ESV)
Time frame: 1, 3, 6 months, 1, 4 years
wall motion score index(WMSI)
Time frame: 1, 3, 6 months, 1, 4 years
cumulative MACE(including cardiac death, non-fetal myocardial infarction and target lesion revascularization)
Time frame: 1, 3, 6 months, 1, 4 years
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