Distribution of Topical Nasal Medication Within the Nasal Cavity and Sinuses by Radiographic Comparison

University of Nebraska18 enrolled

Overview

The purpose of this study is to determine the distribution of nasal sprays and nasal drops when used.

The purpose of this study is to determine the distribution of nasal sprays and nasal drops when used. The study hypothesizes that nasal drops will reach the frontonasal region more often than nasal sprays.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

OTHER

Masking

SINGLE

Enrollment

Conditions

Chronic Sinusitis

Interventions

Sinus CT ScanRADIATION

Subjects will undergo a Xoran miniCAT scan of their sinuses

Omnipaque 240 Contrast SolutionDRUG

Subjects will spray 2-4 drops of half-strength Omnipaque 240 mgI/mL into each nare. Each spray is approximately 0.1 ml.

Omnipaque 240 mg I/mLDRUG

Subjects will place two drops of half-strength Omnipaque 240 mg I/mL intranasally to each nose. Each drop is approximately 1 ml.

Eligibility

Sex: ALLMin age: 19 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * adult able to perform activities of daily living Exclusion Criteria: * signs or symptoms of acute or chronic paranasal sinus disease * history of sinus surgery * symptomatic deviated septum * active seasonal allergies * allergies to contrast * history of nasal polyposis * pregnant or breast feeding women * neck or back problems that would prevent a subject from kneeling on the floor and crouching over * currently taking metformin or amiodarone * students or stff under the direct supervision of the investigators * cognitive impairment * terminal illness

Locations (1)

ENT Specialist PC of Omaha

Omaha, Nebraska, United States

Outcomes

Primary Outcomes

To Measure the Distribution of Nasal Sprays and Drops.

CT scan scored for distribution contrast delivered by nasal spray or drops within subsets in the nasal cavity. The sinonasal cavity was divided into twenty-one subsites on each side of the nasal cavity. The interpreters scored for the presence (1) or absence (0) of contrast from the nasal spray or nasal drops within each subsite. Left and right sides were interpreted separately for a possible total score of 0-42 for each CT scan.

Time frame: 2 months

Data from ClinicalTrials.gov

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