Oral Glucocorticosteroid in the Treatment of Severe Asthma Exacerbation in Hospitalized Patients

Hamamatsu University50 enrolled

Overview

A comparison of oral prednisolone administration with intravenous methylprednisolone infusion in the treatment of acute asthma exacerbation in hospitalized patients. Oral glucocorticosteroids administration may be effective as intravenous high-dose methylprednisolone infusion.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Asthma

Interventions

methylprednisolone sodium succinate (mPSL)DRUG

mPSL IV 240mg per day for 5 days and oral PSL 40mg per day for 5 days

prednisolone (PSL)DRUG

PSL 40 mg per day for 10 days

Eligibility

Sex: ALLMin age: 16 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Asthma patients, who need hospitalized treatment, who do not respond with initial treatment including bronchodilator and IV methylprednisolone therapy Exclusion Criteria: * Need for incubation * With severe complications * Received systemic glucocorticosteroid therapy in the previous 4 weeks

Locations (1)

Hamamatsu University School of Medicine

Hamamatsu, Japan

Outcomes

Primary Outcomes

Efficacy of oral prednisolone for the treatment of acute asthma

Time frame: three-year

Secondary Outcomes

The safety of oral prednisolone for the treatment of acute asthma

Time frame: three-year

Data from ClinicalTrials.gov

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