Eight-week multi-national, multicenter, randomized, double blind, active control, two arms, parallel groups study with a 4-week single drug treatment (manidipine or amlodipine) phase followed by a 4-week combination treatment (manidipine + delapril or amlodipine + delapril) phase.
The aim of the current study is to assess the effect of a 4-week single drug treatment with manidipine or amlodipine and a 4-week combination treatment with manidipine plus delapril or amlodipine plus delapril on intraglomerular pressure in subjects with hypertension.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Enrollment
100
amlodipine 10 mg once daily
manidipine 20 mg once daily
amlodipine 5 mg + delapril 30 mg once daily
Clinical Research Center, Department of Nephrology and Hypertension, University of Erlangen-Nurnberg
Erlangen, Bavaria, Germany
effect of manidipine 20 mg once daily compared to amlodipine 10 mg once daily on intraglomerular pressure
Time frame: 4 weeks
effects of combination of manidipine 10 mg plus delapril 30 mg once daily compared with once daily amlodipine 5 mg plus delapril 30 mg on intraglomerular pressure
Time frame: 4 weeks
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manidipine 10 mg + delapril 30 mg once daily