Mechanisms Responsible for Cardiac and Skeletal Muscle Energetic Impairment in Diabetes

Inclusion Criteria: * Diabetes Mellitus(WHO definition) * HbA1C \<9 * No history of chest pain * No evidence of Coronary Artery Disease or peripheral vascular disease * Left ventricular ejection fraction over 50% * No evidence of respiratory disease Exclusion Criteria: * Patients \< 16years or who cannot provide informed consent * Evidence of significant epicardial coronary artery disease * Evidence of peripheral vascular disease * Abnormal liver function tests * Clinically apparent peripheral neuropathy * Severe chronic renal failure (creatinine \>250) or diabetic nephropathy * Concomitant use of Amiodarone, Quinidine, Haloperidol or Selective serotonin (5HT) uptake inhibitors such as Fluoxetine and Paroxetine which may inhibit the CYP2D6 enzyme * Patients on statin therapy for primary dyslipidemia. * Patients with recurrent hypoglycaemia * Women of child bearing age who are not using effective contraception (or if pregnancy test positive)