A Multicenter, Randomized, Double-Blind, Placebo-Controlled Efficacy Study Comparing 4 Weeks of Treatment With Esomeprazole 20 mg qd and 40 mg qd to Placebo qd in Patients With Heartburn and Sleep Disturbances Associated With Gastroesophageal Reflux Disease (GERD)

Inclusion Criteria: * A history of heartburn or acid regurgitation for 3 months or longer or any history of erosive esophagitis. * Nightime heartburn averaging at least 2 or 3 times per week and a history of sleep disturbances associated with GERD for 1 month or more. * Nightime heartburn graded as moderate or severe on 3 of the last 7 days of the run-in period and sleep disturbances associated with GERD as documented in the run-in diary card on at least 3 of the last 7 days of the run-in period.. Exclusion Criteria: * Any condition other than GERD that is either the primary cause of, or a significant contributor to the patients sleep disturbance. * Shift workers who work between 12am (midnight) and 6am. * Sleep medication, antihistamine, benzodiazepine, or anti-anxiety medication use that has not been stable for at least 3 months or is not expected to remain stable during the patients participation in the study. * Other diseases / conditions as listed in the protocol.