This study aims to investigate whether the atypical antipsychotic and mixed 5-HT2/D2 antagonist sertindole modulates or improves both subcortical and cortical information processing in schizophrenic patients who had not or insufficiently responded to previous antipsychotic medication. This goal shall be accomplished by investigating the effect of sertindole of both prepulse inhibition of the acoustic startle (PPI) and P50 suppression of auditory evoked potentials in schizophrenic patients. These effects shall be compared to the effect of risperidone and shall also be compared to untreated healthy controls.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
SINGLE
Enrollment
14
oral 12-20 mg/day
oral 2-6mg / day
University Hospital of Psychiatry, Department Neuropsychopharmacology and Brain Imaging
Zurich, Canton of Zurich, Switzerland
sensory (EEG: P50 suppression) and sensorimotor gating (EMG: PPI)
Time frame: Before and six weeks after antipsychotic treatment
Cognitive performances
Time frame: Before and six weeks after antipsychotic treatment
Psychopathology (PANSS rating)
Time frame: Before and six weeks after antipsychotic treatment
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