PUVA Versus PUVA + IFN Alpha 2a in Mycosis Fungoides

Inclusion Criteria: * Mycosis fungoides Stage Ia Ib IIa * Written informed consent * 18-70 y.o., both sex * No concomitant systemic disease Exclusion Criteria: * Pregnant or lactating women * Fertile women not accepting contraception * Medical history of melanoma or non melanoma skin cancer * Concomitant infections * Immunodeficiency states * Previous Heart disease * Respiratory insufficiency * Chronic RRenal insufficiency * Chronic hepatopathy * Epilepsy * Depression * Leucocytes \<3000 or neutrophiles \<1000 or thrombocytes \<100000 or hemoglobin \<12 gr/dL or ANA \<1/80 * Treatment with systemic steroids * Altered thyroid hormones * Previous resistance to PUVA and/or IFN * Hypersensitivity to IFN * Patients under treatment with teophiline and/or dicumarol * Previous total skin electron beam * Wash up period less than 3 month for IFN and /or PUVA * Wash up period less than 1 month for topical treatments