Cannulation for Resuscitation

Overview

International CPR guidelines recommend the cannulation of a peripheral vein (antecubital or external jugular) during resuscitation. One reason for preferring the external jugular vein over more peripheral veins is the faster circulation time of drugs during CPR. The differences in circulation time may be over 90 seconds between peripheral and central (internal jugular) veins. However, cannulation of the external jugular vein may be more difficult and time consuming than cannulating cubital veins. There are no studies on the success rate, cannulation time and reliability of venous access comparing central and peripheral cannulation sites. We hypothesized that cannulation of the external jugular vein (by paramedics and is a demanding procedure in an emergency situation and should not be recommended during resuscitation. The aims of this study are to compare the feasibility of cannulating the external jugular vein compared to the cubital vein in terms of attempts, cannulation time and reliability of venous access.

The protocol includes measurement of: 1. The time of cannulation 2. Number of attempts of cannulation, Every piercing of skin is counted as one attempt. Maximally three attempts will be allowed. 3. Failures. Perforation of vein and subcutaneous hemorrhage, arterial puncture, the appropriate vein is not found, free back flow of blood or free infusion of saline is not achieved the attempt are considered as failures . Cannulation of another site is then started or the study is ended. The final protocol of the study will be a paired control, randomized prospective study. The randomization will be for the order of cannulation site (internal jugular or cubital vein first) In the final study the cannulation will be performed by emergency department interns and paramedics with advanced cardiac life support skills and licenced by Kuopio University Hospital. For comparison and describing the experience of the paramedics an enquiry is accomplished and the following data are collected: 1. Age 2. Experience as a paramedic (years after graduation) 3. Theoretical guidance of cannulation (self estimated /hours) 4. Practical guidance of cannulation (self estimated/hours) 5. Experience of cannulation of the external jugular vein (self estimated/times) For comparison and describing the experience of the interns in the ER a similar enquiry is accomplished,: 1. Age 2. Experience as an intern (years after graduation as MD) 3. Theoretical guidance of cannulation (self estimated /hours) 4. Practical guidance of cannulation (self estimated/hours) 5. Cannulation of external jugular vein (self estimated/times) Statistical analysis The primary endpoint in this study is cannulation time of the two sites (internal jugular and cubital vein). The secondary end points are failure/success of cannulation and reliability of venous access as defined above. Patient characteristics and anesthetic and operative variables are compared with the t-test for independent samples (continuous variables), or the Mann-Whitney U-test and 2-test (Pearson) or Fishers exact test when appropriate (categorical variables). Cannulation time differences between the groups will be compared with the t-test for independent samples (after tests for homoscedasticity and normality) or Mann-Whitney U-test if appropriate. Success of cannulation will be compared with 2-test (Pearson) or Fishers exact test when appropriate. A p value less than 0.05 is considered statistically significant. Results are given as mean (SD) or number of patients. All statistical analyses will be performed with SPSS version 11.01 software (SPSS Inc, Chicago, IL, USA).