Interaction Between Antihypertensives and Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)

University of Split88 enrolled

Overview

NSAIDs may increase blood pressure and blunt the effects of many antihypertensives. Members of these drug classes differ in their propensity to such an interaction.

To compare prospectively the effects of piroxicam, ibuprofen and acetaminophen on blood pressure control in hypertensive patients with osteoarthritis.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

Conditions

Hypertension

Interventions

acetaminophenDRUG

acetaminophen 1000 mg t.i.d. per os ibuprofen 400-600 mg t.i.d. per os piroxicam 10-20 mg o.d. per os

ibuprofenDRUG

acetaminophen 1000 mg t.i.d. per os ibuprofen 400-600 mg t.i.d. per os piroxicam 10-20 mg o.d. per os

piroxicamDRUG

acetaminophen 1000 mg t.i.d. per os ibuprofen 400-600 mg t.i.d. per os piroxicam 10-20 mg o.d. per os

Eligibility

Sex: ALLMin age: 55 YearsMax age: 78 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Treated hypertensives of either gender aged between 55 and 76 years * About 50% with concomitant osteoarthritis of the hip or knee Exclusion Criteria: * Normotensive persons or untreated hypertensives * Individuals outside the age limits * General exclusion criteria (e.g. uncooperative persons, advanced malignancies, participants in other studies)

Locations (1)

Split University School of Medicine. Family Practice Department

Split, Croatia

Outcomes

Primary Outcomes

Arterial blood pressure

Time frame: 3 months (3 individual blocks of 1 month each)

Secondary Outcomes

Body weight,serum electrolytes, urinary electrolytes (Na, K)

Time frame: 3 months (3 periods of 1 month)

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.