Assessment of Changes in Renal Cortical and Medullary Blood Flow by Contrast Ultrasound

University of Virginia20 enrolled

Overview

The purpose of this study is to determine if contrast enhanced ultrasound (CEU) using microbubbles, is useful in assessing changes in kidney blood flow.

Study Type

INTERVENTIONAL

Allocation

Purpose

DIAGNOSTIC

Masking

NONE

Enrollment

Conditions

Kidney

Interventions

perflutren lipid microspheresDRUG

1.3 ml in 30 ml of saline, infused into vein at 2ml / min and titrated for optimal image quality (not to exceed 10 ml/ min at any time).

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Healthy adults * Males and females * Ages 18-65 years old Exclusion Criteria: * Pregnancy or lactation * H/o kidney disease * H/o congestive heart failure, ischemic heart disease, severe pulmonary disease or allergy to the drug * H/o any cardiovascular disease * Abnormal liver function (liver function tests out of specified ranges) * Screening urinalysis which indicates infection or inflammation * Taking regular medications (except for over-the-counter vitamins or hormonal contraceptives.) * Taking supplements, like protein shakes * Unwilling or unable to eat chicken (used as protein meal)

Locations (1)

University of Virginia Health System

Charlottesville, Virginia, United States

RECRUITING

Central Contacts

Kambiz Kalantarinia, MD

CONTACT

434 924 5125 kk6c@virginia.edu

Lori Ratliff, RN ANP

CONTACT

434 924 5820 lbr@virginia.edu

Data from ClinicalTrials.gov

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