Continuous Positive Airway Pressure and Oxygen Concentration on Measurement of Rapid Shallow Breathing Index

Taipei Veterans General Hospital, Taiwan98 enrolled

Overview

To compare the rapid shallow breathing index (RSBI) values, the incidence of adverse reactions, and the predictive accuracy measured under 5 different ventilator strategies in the same patient group.

98 ready for weaning patients were included and divided into success (n=71) and failure (n=27) groups based upon their weaning outcome. Before weaning, the RSBI values were determined under the patients disconnecting from the ventilator (RA-no ventilator) and still connecting to the ventilator with 4 different settings (fraction of inspired oxygen (FiO2) 21 or 40% combined with continuous positive airway pressure (CPAP) 0 or 5 cm H2O). The patients were extubated after completing the weaning trials. Successful weaning was defined as patients free from the ventilator for over 48 hours.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Acute Respiratory Failure

Eligibility

Sex: ALL

Medical Language ↔ Plain English

Inclusion Criteria: * intubated medical patients with mechanically ventilated more than 48 hours * clinically ready for weaning * Glasgow coma scales were at least 8 * their ventilator settings were: assist-controlled, pressure support (PS)or synchronized intermittent mandatory ventilation plus PS mode, FiO2 40% or less, positive end-expiratory pressure 5 cm H2O or less, and sensitivity setting on 1 L/min. Their arterial blood gases results were acceptable Exclusion Criteria: * having ongoing lung or neuromuscular disease and signs of increased intracranial pressure

Locations (1)

Respiratory Therapy Intensive Care Unit, Taipei Veterans General Hospital

Taipei, Taiwan

Outcomes

Primary Outcomes

The patients connecting or disconnecting to the ventilators affected the RSBI values but not their predictive accuracies.

Time frame: Before the patient processing weaning trials

Secondary Outcomes

Changes in FiO2 and CPAP settings have no effect on RSBI values but ventilator methods with FiO2 21% have higher incidence of adverse reactions.

Time frame: Before the patient processing weaning trials

Data from ClinicalTrials.gov

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